2986747-52-6
2986747-52-6
Chemical Structure
mTOR/HDAC6-IN-1
- CAS No.: 2986747-52-6
- Formula:C20H20ClN5O2
- Molecular Weight:397.86
IUPAC Name: 4-(7-chloro-4-(4-methylpiperazin-1-yl)quinazolin-2-yl)-N-hydroxybenzamide
InChIKey: DYZSQWJEPPEPAQ-UHFFFAOYSA-N
SMILES: CN1CCN(CC1)C2=NC(C3=CC=C(C=C3)C(NO)=O)=NC4=CC(Cl)=CC=C42
Biological Activity: mTOR/HDAC6-IN-1 is a potent mTOR and HDAC6 dual inhibitor (IC50s of 133.7 nM and 56 nM for mTOR and HDAC6, respectively). mTOR/HDAC6-IN-1 can induce significant autophagy, apoptosis and suppress migration. mTOR/HDAC6-IN-1 has potential to research Triple-negative breast cancer (TNBC)[1].
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mTOR/HDAC6-IN-1 | mTOR/HDAC6-IN-1 is a potent mTOR and HDAC6 dual inhibitor (IC50s of 133.7 nM and 56 nM for mTOR and HDAC6, respectively). mTOR/HDAC6-IN-1 can induce significant autophagy, apoptosis and suppress migration. mTOR/HDAC6-IN-1 has potential to research Triple-negative breast cancer (TNBC). | |||||||||||||||||||||
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References
Keywords
