2989908-08-7
Chemical Structure
DSM705 hydrochloride
- CAS No.: 2989908-08-7
- Formula:C19H20ClF3N6O
- Molecular Weight:440.85
IUPAC Name: (R)-N-(1-(1H-1,2,4-triazol-5-yl)ethyl)-3-methyl-4-(1-(6-(trifluoromethyl)pyridin-3-yl)cyclopropyl)-1H-pyrrole-2-carboxamide hydrochloride
InChIKey: RHFZUAKKIHNLHI-RFVHGSKJSA-N
SMILES: C[C@H](C1=NC=NN1)NC(C2=C(C(C3(C4=CC=C(N=C4)C(F)(F)F)CC3)=CN2)C)=O.[H]Cl
Biological Activity: DSM705 hydrochloride, an orally active antimalarial compound, is a pyrrole-based Dihydroorotate Dehydrogenase (DHODH) inhibitor. DSM705 hydrochloride exhibits nanomolar potency against Plasmodium DHODH and Plasmodium parasites (IC50=95, 52 nM for P. falciparum and P. vivax DHODH, respectively), with no inhibition of mammalian DHODHs[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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DSM705 hydrochloride | 98.22% | DSM705 hydrochloride, an orally active antimalarial compound, is a pyrrole-based Dihydroorotate Dehydrogenase (DHODH) inhibitor. DSM705 hydrochloride exhibits nanomolar potency against Plasmodium DHODH and Plasmodium parasites (IC50=95, 52 nM for P. falciparum and P. vivax DHODH, respectively), with no inhibition of mammalian DHODHs. | ||||||||||||||||||||
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Keywords
