2991254-59-0
2991254-59-0
Chemical Structure
Homocarnosine TFA
Synonym(s): L-Homocarnosine TFA
- CAS No.: 2991254-59-0
- Formula:C12H17F3N4O5
- Molecular Weight:354.28
IUPAC Name: L-glutamine-5-13C
InChIKey: UESNJLCFYZRAFK-QRPNPIFTSA-N
SMILES: O=C(O)C(F)(F)F.O=C([C@@H](NC(CCCN)=O)CC1=CNC=N1)O
Biological Activity: Homocarnosine TFA is a dipeptide of γ-aminobutyric acid (GABA) and histidine unique to brain. Homocarnosine TFA is an inhibitory neuromodulator synthesized in the neuron from GABA and exhibiting anticonvulsant effects[1]. Homocarnosine TFA has antioxidant and anti-inflammatory actions, prevention of DNA damage, and inhibition of advanced glycation end-product formation[2].
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Homocarnosine TFA | Homocarnosine TFA is a dipeptide of γ-aminobutyric acid (GABA) and histidine unique to brain. Homocarnosine TFA is an inhibitory neuromodulator synthesized in the neuron from GABA and exhibiting anticonvulsant effects. Homocarnosine TFA has antioxidant and anti-inflammatory actions, prevention of DNA damage, and inhibition of advanced glycation end-product formation. | |||||||||||||||||||||
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References
- [1]. Petroff OA, et al. Vigabatrin increases human brain homocarnosine and improves seizure control. Ann Neurol. 1998;44(6):948-952. [Content Brief]
- [2]. Kumrungsee T, et al. Dietary GABA induces endogenous synthesis of a novel imidazole peptide homocarnosine in mouse skeletal muscles. Amino Acids. 2020;52(5):743-753. [Content Brief]
