2991637-98-8
Chemical Structure
DB008
- CAS No.: 2991637-98-8
- Formula:C25H21FN4O3
- Molecular Weight:444.46
IUPAC Name: 4-(3-(4-acryloylpiperazine-1-carbonyl)-4-fluorobenzyl)-6-ethynylphthalazin-1(2H)-one
InChIKey: FDHSVRMVJBTBMG-UHFFFAOYSA-N
SMILES: O=C1NN=C(CC2=CC=C(F)C(C(N3CCN(C(C=C)=O)CC3)=O)=C2)C4=C1C=CC(C#C)=C4
Biological Activity: DB008 is potent and selective PARP16 inhibitor with an IC50 value of 0.27 μM, containing an acrylamide electrophilic reagent. DB008 is membrane-permeable and marks PARP16 selectively[1]. DB008 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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DB008 | 98.47% | DB008 is potent and selective PARP16 inhibitor with an IC50 value of 0.27 μM, containing an acrylamide electrophilic reagent. DB008 is membrane-permeable and marks PARP16 selectively. DB008 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | ||||||||||||||||||||
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