29953-50-2
29953-50-2
Chemical Structure
Roridin H
Synonym(s): Verrucarin H
- CAS No.: 29953-50-2
- Formula:C29H36O8
- Molecular Weight:512.59
InChIKey: IWFOIUWPNYEUAI-YRWBHIADSA-N
SMILES: CC1=C[C@]2([H])[C@]([C@]3(C)[C@@]4(OC4)[C@](C[C@H]3OC(/C=C\C=C\C(O5)C(C)OC5C/C(C)=C\6)=O)([H])O2)(COC6=O)CC1
Biological Activity: Roridin H (Verrucarin H) is a cytostatic antibiotic present in the Myrothecium verrucaria strain and the marine-derived Myrothecium sp. TUF 02F6. The IC50 of Roridin H against mouse leukemia cells is 0.12 mM. Roridin H can be used in leukemia-related research[1][2].
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Roridin H | Roridin H (Verrucarin H) is a cytostatic antibiotic present in the Myrothecium verrucaria strain and the marine-derived Myrothecium sp. TUF 02F6. The IC50 of Roridin H against mouse leukemia cells is 0.12 mM. Roridin H can be used in leukemia-related research. | |||||||||||||||||||||
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References
- [1]. Traxler P. Die Struktur des Antibioticums Roridin H. Verrucarine und Roridine, 20. Mitt. Helvetica Chimica Acta, 1970, 53(7):1846‑1869.
- [2]. Xu J, et al. Four new macrocyclic trichothecenes from two strains of marine-derived fungi of the genus Myrothecium. The Journal of antibiotics. 2006 Aug;59(8):451-5. [Content Brief]
