3001295-81-1
3001295-81-1
Chemical Structure
PTP1B-IN-20
- CAS No.: 3001295-81-1
- Formula:C26H28O15
- Molecular Weight:580.49
IUPAC Name: 6'-chloro-[2,2'-bipyridin]-6-ol
InChIKey: FATNCJZCOOPLKZ-YJWXBJJPSA-N
SMILES: OC1=C(C2=C(C(C3=C(C2=O)C=C(C(C)=C3O)O[C@H]4[C@H](O)[C@H]([C@@H]([C@H](O4)CO[C@@H]5OC[C@@H](O)[C@H](O)[C@H]5O)O)O)=O)C=C1)O
Biological Activity: PTP1B-IN-20 is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B; IC50=1.05 μM) over the highly homologous T-cell protein tyrosine phosphatase (TCPTP; IC50=78.0 μM), which is a key target for type 2 diabetes inhibition[1].
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PTP1B-IN-20 | PTP1B-IN-20 is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B; IC50=1.05 μM) over the highly homologous T-cell protein tyrosine phosphatase (TCPTP; IC50=78.0 μM), which is a key target for type 2 diabetes inhibition. | |||||||||||||||||||||
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