3020773-81-0
Chemical Structure
CDK9 degrader-2
- CAS No.: 3020773-81-0
- Formula:C32H40N4O6S2
- Molecular Weight:640.81
InChIKey: RWPZOWQNLQTXKM-UHFFFAOYSA-N
SMILES: CC(C)(C1=CN=C(O1)CSC2=CN=C(S2)NC(C3CCN(CC3)CCCCCOC4=C5C(OC(C=C5C)=O)=CC(O)=C4)=O)C
Biological Activity: CDK9 degrader-2 is a bifunctional degrader of ATTEC (Autophagy-Tethering Compound) that degrades the CDK9/cyclin T1 complex. CDK9 degrader-2 forms a ternary complex with CDK9 and LC3B, and achieves degradation through the autophagy-lysosome pathway, a process independent of the ubiquitin-proteasome system. CDK9 degrader-2 downregulates the expression of Mcl-1 and c-Myc proteins, induces apoptosis, and exhibits antitumor activity in in vivo MV4-11 xenograft models. CDK9 degrader-2 can be used for leukemia research[1].
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CDK9 degrader-2 | CDK9 degrader-2 is a bifunctional degrader of ATTEC (Autophagy-Tethering Compound) that degrades the CDK9/cyclin T1 complex. CDK9 degrader-2 forms a ternary complex with CDK9 and LC3B, and achieves degradation through the autophagy-lysosome pathway, a process independent of the ubiquitin-proteasome system. CDK9 degrader-2 downregulates the expression of Mcl-1 and c-Myc proteins, induces apoptosis, and exhibits antitumor activity in in vivo MV4-11 xenograft models. CDK9 degrader-2 can be used for leukemia research. | |||||||||||||||||||||
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