3026839-88-0
Chemical Structure
DHODH-IN-33
- CAS 番号: 3026839-88-0
- Formula:C23H21NO4S
- Molecular Weight:407.48
InChIKey: VCPXLSVCBZVDCZ-UHFFFAOYSA-N
SMILES: COC1=CC2=C(N(C3C4=CC=CC=C4OC3C2)S(=O)(C5=CC=C(C=C5)C)=O)C=C1
Biological Activity: DHODH-IN-33 is a selective dihydroorotate dehydrogenase (DHODH) inhibitor with potent activity against A549 (IC50 = 5.22 μM) and 5637 (IC50 = 3.03 μM). DHODH-IN-33 induces autophagy-dependent ferroptosis (mitochondrial dysfunction, lipid peroxidation, and ROS accumulation) with no notable toxicity in vivo. DHODH-IN-33 exerts anti-cancer effect by promoting the autophagy-dependent degradation of DHODH. DHODH-IN-33 can be used for non-small cell lung cancer and bladder cancer[1].
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DHODH-IN-33 | DHODH-IN-33 is a selective dihydroorotate dehydrogenase (DHODH) inhibitor with potent activity against A549 (IC50 = 5.22 μM) and 5637 (IC50 = 3.03 μM). DHODH-IN-33 induces autophagy-dependent ferroptosis (mitochondrial dysfunction, lipid peroxidation, and ROS accumulation) with no notable toxicity in vivo. DHODH-IN-33 exerts anti-cancer effect by promoting the autophagy-dependent degradation of DHODH. DHODH-IN-33 can be used for non-small cell lung cancer and bladder cancer. | |||||||||||||||||||||
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