3031972-21-8
3031972-21-8
Chemical Structure
Tyrosine kinase-IN-11
- CAS No.: 3031972-21-8
- Formula:C25H20N2O
- Molecular Weight:364.44
InChIKey: NDNHHMYAOLMSJC-HMAPJEAMSA-N
SMILES: O=C1N(CC2=CC=CC=C2)C3=CC=C(C)C=C3/C1=C/C4=CNC5=CC=CC=C45
Biological Activity: Tyrosine kinase-IN-11 (Compound 4b) is a tyrosine kinase inhibitor. Tyrosine kinase-IN-11 decreases general tyrosine kinase activity, selectively inhibits PDGFR-β, SRC, and c-MET kinases. Tyrosine kinase-IN-11 induces apoptosis, accompanied by reduced ERK signalings. Tyrosine kinase-IN-11 exhibits selective anticancer activity against pancreatic cancer and renal cancer[1].
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Tyrosine kinase-IN-11 | 98.75% | Tyrosine kinase-IN-11 (Compound 4b) is a tyrosine kinase inhibitor. Tyrosine kinase-IN-11 decreases general tyrosine kinase activity, selectively inhibits PDGFR-β, SRC, and c-MET kinases. Tyrosine kinase-IN-11 induces apoptosis, accompanied by reduced ERK signalings. Tyrosine kinase-IN-11 exhibits selective anticancer activity against pancreatic cancer and renal cancer. | ||||||||||||||||||||
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References
Keywords
