3034297-25-8
Chemical Structure
Bax activator-2
- CAS No.: 3034297-25-8
- Formula:C30H23N3O5
- Molecular Weight:505.52
InChIKey: BWHSOFRVDKPRNR-UHFFFAOYSA-N
SMILES: OC(C1=CC=C(C2=CC(NC3=CC=CC=C3[N+]([O-])=O)=CC=C2OC4=CC=C(C(C)=C4)C5=CC=CC=C5)N1)=O
Biological Activity: Bax activator-2 is a pro-apoptotic agent targeting BAX, with an IC50 of 0.30 μM against human BAX. Bax activator-2 binds to the trigger site of BAX and induces its conformational change. Bax activator-2 induces mitochondrial depolarization, cytochrome c release, cleavage of caspase-3/9 and PARP, thereby initiating apoptosis. Bax activator-2 exhibits cytotoxicity against a variety of cancer cell lines. Bax activator-2 can be used in research related to acute myeloid leukemia and solid tumors[1].
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Bax activator-2 | Bax activator-2 is a pro-apoptotic agent targeting BAX, with an IC50 of 0.30 μM against human BAX. Bax activator-2 binds to the trigger site of BAX and induces its conformational change. Bax activator-2 induces mitochondrial depolarization, cytochrome c release, cleavage of caspase-3/9 and PARP, thereby initiating apoptosis. Bax activator-2 exhibits cytotoxicity against a variety of cancer cell lines. Bax activator-2 can be used in research related to acute myeloid leukemia and solid tumors. | |||||||||||||||||||||
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