3035189-46-6
3035189-46-6
Chemical Structure
PROTAC HDAC4 Degrader-2
- CAS No.: 3035189-46-6
- Formula:C52H73F3N8O11S
- Molecular Weight:1075.24
InChIKey: KBDZFZJFGKYVBZ-KLSSUPLUSA-N
SMILES: O=C(C1=CC=C(C2=NOC(C(F)(F)F)=N2)C=C1)N[C@H](C)CN(CCC)CCCCOCCOCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N3[C@@H](C[C@H](C3)O)C(NCC4=CC=C(C5=C(N=CS5)C)C=C4)=O)=O)=O
Biological Activity: PROTAC HDAC4 Degrader-2 is a class IIa selective negative control for HDAC4 PROTAC degraders, with an IC50 of 0.15 μM against HDAC4 and a cellular IC50 of 0.18 μM. PROTAC HDAC4 Degrader-2 fails to effectively recruit the VHL E3 ligase, and thus does not induce significant degradation of HDAC4 protein[1].
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PROTAC HDAC4 Degrader-2 | PROTAC HDAC4 Degrader-2 is a class IIa selective negative control for HDAC4 PROTAC degraders, with an IC50 of 0.15 μM against HDAC4 and a cellular IC50 of 0.18 μM. PROTAC HDAC4 Degrader-2 fails to effectively recruit the VHL E3 ligase, and thus does not induce significant degradation of HDAC4 protein. | |||||||||||||||||||||
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