3037398-18-5
Chemical Structure
EGFR-IN-189
- CAS No.: 3037398-18-5
- Formula:C26H26N6O
- Molecular Weight:438.52
InChIKey: NPILDBQNORECNB-UHFFFAOYSA-N
SMILES: O=C(C=C1C#C)N(C2=CC=CC=C2)C3=C1C=NC(NC4=CC=C(N(C)CCN(C)C)C=C4)=N3
Biological Activity: EGFR-IN-189 (Compound 7) is a selective covalent epidermal growth factor receptor (EGFR) inhibitor with an IC50 of 200 nM. EGFR-IN-189 can effectively inhibit the C797S mutant type of EGFR. EGFR-IN-189 can inhibit cancer cells proliferation and inhibit EGFR phosphorylation and downstream ERK1/2 phosphorylation. EGFR-IN-189 can be used for research of nonsmall cell lung cancer[1].
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EGFR-IN-189 | EGFR-IN-189 (Compound 7) is a selective covalent epidermal growth factor receptor (EGFR) inhibitor with an IC50 of 200 nM. EGFR-IN-189 can effectively inhibit the C797S mutant type of EGFR. EGFR-IN-189 can inhibit cancer cells proliferation and inhibit EGFR phosphorylation and downstream ERK1/2 phosphorylation. EGFR-IN-189 can be used for research of nonsmall cell lung cancer. | |||||||||||||||||||||
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Keywords
