3038446-90-8
3038446-90-8
Chemical Structure
JB300
- CAS No.: 3038446-90-8
- Formula:C43H45ClFN7O10S
- Molecular Weight:906.37
InChIKey: LAZHTWDJEQSMOY-NKEKBGIASA-N
SMILES: O=C(N1C2C(NC(CC2)=O)=O)C3=CC=CC(OCC(NCCOCCOCCNC([C@@]4(CC[C@H](CC4)OC5=C(C(Cl)=CC=C5)F)CC6=CC=CC(NC7=NC=CS7)=N6)=O)=O)=C3C1=O
Biological Activity: JB300 is a PROTAC degrader that selectively targets and degrades AURORA-A by recruiting cereblon, with EC50 values of 373 nM and 193 nM in intact cells and permeabilized cells, respectively. JB300 can be used in studies related to acute myeloid leukemia and targeted protein degradation mechanisms[1].
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JB300 | 98% | JB300 is a PROTAC degrader that selectively targets and degrades AURORA-A by recruiting cereblon, with EC50 values of 373 nM and 193 nM in intact cells and permeabilized cells, respectively. JB300 can be used in studies related to acute myeloid leukemia and targeted protein degradation mechanisms. | ||||||||||||||||||||
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References
Keywords
