3040997-52-9
Chemical Structure
PPL agonist-1
- CAS No.: 3040997-52-9
- Formula:C25H22FN5O4S
- Molecular Weight:507.54
InChIKey: AGLCDRFCRKVYEC-KRWDZBQOSA-N
SMILES: CC1=C(F)C=CC(C2=CC=C([C@@H](NC3=NC(NS(=O)(C4=CC([N+]([O-])=O)=CC=C4)=O)=CC=N3)C)C=C2)=C1
Biological Activity: PPL agonist-1 is a highly selective Periplakin (PPL) agonist that increases cAMP levels by regulating PPL, thereby enhancing MITF expression and promoting melanin synthesis. Furthermore, PPL agonist-1 facilitates melanin production by regulating tryptophan metabolism. Compared to Ruxolitinib (HY-50856), PPL agonist-1 demonstrates superior efficacy. PPL agonist-1 holds potential for research into vitiligo treatment[1].
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PPL agonist-1 | PPL agonist-1 is a highly selective Periplakin (PPL) agonist that increases cAMP levels by regulating PPL, thereby enhancing MITF expression and promoting melanin synthesis. Furthermore, PPL agonist-1 facilitates melanin production by regulating tryptophan metabolism. Compared to Ruxolitinib (HY-50856), PPL agonist-1 demonstrates superior efficacy. PPL agonist-1 holds potential for research into vitiligo treatment. | |||||||||||||||||||||
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Keywords
