3042104-73-1
3042104-73-1
Chemical Structure
EGFR-IN-78
- CAS No.: 3042104-73-1
- Formula:C23H32BrN7O2S
- Molecular Weight:550.51
InChIKey: QKTZQGNZRPKRGC-GOSISDBHSA-N
SMILES: BrC1=C(N[C@@H]2CCCN(S(C3CC3)(=O)=O)C2)N=C(NC4=CC=C(N5CCN(C)CC5)C=C4)N=C1
Biological Activity: EGFR-IN-78 (compound A5)，a 2-aminopyrimidine derivative，is a reversible inhibitor of EGFRC797S-TK，and also an inducer of apoptosis. EGFR-IN-78 shows anti-proliferative activity，inhibits EGFR phosphorylation and arrests cell cycle at G2/M phase[1].
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EGFR-IN-78 | 99.57% | EGFR-IN-78 (compound A5)，a 2-aminopyrimidine derivative，is a reversible inhibitor of EGFRC797S-TK，and also an inducer of apoptosis. EGFR-IN-78 shows anti-proliferative activity，inhibits EGFR phosphorylation and arrests cell cycle at G2/M phase. | ||||||||||||||||||||
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