EGFR-IN-78
Based on 1 Customer Validation
EGFR-IN-78 (compound A5)，a 2-aminopyrimidine derivative，is a reversible inhibitor of EGFRC797S-TK，and also an inducer of apoptosis. EGFR-IN-78 shows anti-proliferative activity，inhibits EGFR phosphorylation and arrests cell cycle at G2/M phase.
For research use only. We do not sell to patients.
- Purity: 99.57%
- CAS No.: 3042104-73-1
- Formula: C23H32BrN7O2S
- Molecular Weight:550.51
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Apoptosis Compound Library
HY-L003
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Immunology/Inflammation Compound Library
HY-L007
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JAK/STAT Compound Library
HY-L008
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Kinase Inhibitor Library
HY-L009
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Protein Tyrosine Kinase Compound Library
HY-L016
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Anti-Cancer Compound Library
HY-L025
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Differentiation Inducing Compound Library
HY-L038
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Anti-Hepatitis C Virus Compound Library
HY-L073
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Anti-Lung Cancer Compound Library
HY-L075
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Anti-Pancreatic Cancer Compound Library
HY-L077
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Anti-Obesity Compound Library
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Angiogenesis-Related Compound Library
HY-L088
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Anti-Liver Cancer Compound Library
HY-L101
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Anti-Colorectal Cancer Compound Library
HY-L103
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Anti-Prostate Cancer Compound Library
HY-L124
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Cancer Stem Cells Compound Library
HY-L135
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Membrane Protein-targeted Compound Library
HY-L149
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Membrane Receptor-targeted Compound Library
HY-L150
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Cytokine Inhibitors Library
HY-L161
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Cell Death Library
HY-L162
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Anti-Ovarian Cancer Compound Library
HY-L173
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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Anti-Brain Cancer Compound Library
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Protein Kinase Compound Library
HY-L196
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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
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Cell Proliferation Compound Library
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High-Throughput Bioactive Compound Library
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Posttranslational Modification Library
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All EGFR Isoforms
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Biological Activity
EGFRC797S[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A-431 | IC50 |
0.62 μM
Compound: A5
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Antiproliferative activity against human A-431 cells by MTT assay
Antiproliferative activity against human A-431 cells by MTT assay
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[PMID: 37336419] |
| HCC827 | IC50 |
>3.3 μM
Compound: A5
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Antiproliferative activity against human HCC827 cells by MTT assay
Antiproliferative activity against human HCC827 cells by MTT assay
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[PMID: 37336419] |
| NCI-H1975 | IC50 |
>3.3 μM
Compound: A5
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Antiproliferative activity against human NCI-H1975 cells by MTT assay
Antiproliferative activity against human NCI-H1975 cells by MTT assay
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[PMID: 37336419] |
Chemical Information
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CAS No. 3042104-73-1
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Appearance Solid
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Molecular Weight 550.51
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Formula C23H32BrN7O2S
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Color White to light yellow
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SMILES
BrC1=C(N[C@@H]2CCCN(S(C3CC3)(=O)=O)C2)N=C(NC4=CC=C(N5CCN(C)CC5)C=C4)N=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (181.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8165 mL | 9.0825 mL | 18.1650 mL | 45.4124 mL |
| 5 mM | 0.3633 mL | 1.8165 mL | 3.6330 mL | 9.0825 mL | |
| 10 mM | 0.1816 mL | 0.9082 mL | 1.8165 mL | 4.5412 mL | |
| 15 mM | 0.1211 mL | 0.6055 mL | 1.2110 mL | 3.0275 mL | |
| 20 mM | 0.0908 mL | 0.4541 mL | 0.9082 mL | 2.2706 mL | |
| 25 mM | 0.0727 mL | 0.3633 mL | 0.7266 mL | 1.8165 mL | |
| 30 mM | 0.0605 mL | 0.3027 mL | 0.6055 mL | 1.5137 mL | |
| 40 mM | 0.0454 mL | 0.2271 mL | 0.4541 mL | 1.1353 mL | |
| 50 mM | 0.0363 mL | 0.1816 mL | 0.3633 mL | 0.9082 mL | |
| 60 mM | 0.0303 mL | 0.1514 mL | 0.3027 mL | 0.7569 mL | |
| 80 mM | 0.0227 mL | 0.1135 mL | 0.2271 mL | 0.5677 mL | |
| 100 mM | 0.0182 mL | 0.0908 mL | 0.1816 mL | 0.4541 mL |
EGFR-IN-78 Related Classifications
HY-149889 Related Classifications
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