304896-41-1
304896-41-1
Chemical Structure
UCI-1014
- CAS No.: 304896-41-1
- Formula:C16H12N2O4
- Molecular Weight:296.28
InChIKey: JTKIZRWVKQEKAS-UHFFFAOYSA-N
SMILES: CC1=CC=C(C=C1)C2=CC=C(O2)/C=C3C(NC(NC\3=O)=O)=O
Biological Activity: UCI-1014 is a mutant p53 (p53R175H) corrector/reactivator. UCI-1014 restores the wild-type-like DNA-binding activity of p53R175H, promotes the redistribution of the mutant protein to chromatin, and induces the expression of p53-dependent target genes. UCI-1014 inhibits the proliferation of p53R175H-mutant cancer cells through an SLC7A11-independent mechanism. UCI-1014 can be used for research related to p53-mutant cancers[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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UCI-1014 | 98.43% | UCI-1014 is a mutant p53 (p53R175H) corrector/reactivator. UCI-1014 restores the wild-type-like DNA-binding activity of p53R175H, promotes the redistribution of the mutant protein to chromatin, and induces the expression of p53-dependent target genes. UCI-1014 inhibits the proliferation of p53R175H-mutant cancer cells through an SLC7A11-independent mechanism. UCI-1014 can be used for research related to p53-mutant cancers. | ||||||||||||||||||||
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