3049715-81-0
3049715-81-0
Chemical Structure
Antileishmanial agent-19
- CAS No.: 3049715-81-0
- Formula:C22H18N4O3
- Molecular Weight:386.40
InChIKey: AHVJHWKOAINDDR-UHFFFAOYSA-N
SMILES: O=C(NC1=NC=CC=C1)COC2=CC=C(C(N3C)=NC4=C(C=CC=C4)C3=O)C=C2
Biological Activity: Antileishmanial agent-19 (Compound F27) is an antileishmanial agent, with a IC50 of 3.39 μM for L. donovani promastigotes. Antileishmanial agent-19 inhibits Leishmania prolyl-tRNA synthetase. Antileishmanial agent-19 inhibits host PI3K/Akt/CREB axis-mediated IL-10 secretion. Antileishmanial agent-19 induces autophagy-mediated apoptosis in L. donovani promastigotes. Antileishmanial agent-19 reduces parasite burden in L.d-infected animals[1].
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Antileishmanial agent-19 | 99.45% | Antileishmanial agent-19 (Compound F27) is an antileishmanial agent, with a IC50 of 3.39 μM for L. donovani promastigotes. Antileishmanial agent-19 inhibits Leishmania prolyl-tRNA synthetase. Antileishmanial agent-19 inhibits host PI3K/Akt/CREB axis-mediated IL-10 secretion. Antileishmanial agent-19 induces autophagy-mediated apoptosis in L. donovani promastigotes. Antileishmanial agent-19 reduces parasite burden in L.d-infected animals. | ||||||||||||||||||||
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