3050643-44-9
Chemical Structure
Sigma-1 receptor antagonist 7
- CAS 番号: 3050643-44-9
- Formula:C22H32N2O
- Molecular Weight:340.50
InChIKey: WUXIZKGFCLDCOJ-UHFFFAOYSA-N
SMILES: O=C1N(CC2CCCC2)CC3(CCN(CCC4=CC=CC=C4)CC3)C1
Biological Activity: Sigma-1 receptor antagonist 7 is a selective sigma-1 receptor antagonist capable of crossing the blood-brain barrier, with an IC50 of 12.7 nM against guinea pig σ1R. Sigma-1 receptor antagonist 7 binds to σ1R, and its binding affinity decreases in the presence of Phenytoin (HY-B0448). Sigma-1 receptor antagonist 7 alleviates mechanical and thermal hyperalgesia induced by acute inflammation in rats. Sigma-1 receptor antagonist 7 can be used for research related to hyperalgesia[1].
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Sigma-1 receptor antagonist 7 | Sigma-1 receptor antagonist 7 is a selective sigma-1 receptor antagonist capable of crossing the blood-brain barrier, with an IC50 of 12.7 nM against guinea pig σ1R. Sigma-1 receptor antagonist 7 binds to σ1R, and its binding affinity decreases in the presence of Phenytoin (HY-B0448). Sigma-1 receptor antagonist 7 alleviates mechanical and thermal hyperalgesia induced by acute inflammation in rats. Sigma-1 receptor antagonist 7 can be used for research related to hyperalgesia. | |||||||||||||||||||||
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Keywords
