3051563-45-9
3051563-45-9
Chemical Structure
PARP7-IN-27
- CAS No.: 3051563-45-9
- Formula:C15H11F4N3O2
- Molecular Weight:341.26
InChIKey: NYPXKOBPJGQJTP-UHFFFAOYSA-N
SMILES: O=C1C(C(F)(F)F)=C(N2CC(C(C3=CC=C(F)C=C3)=O)C2)C=NN1
Biological Activity: PARP7-IN-27 is a blood-brain barrier-permeable and selective PARP7 inhibitor with an IC50 of 22.8 nM. PARP7-IN-27 alleviates neuroinflammation and astrocyte activation, mitigates autophagy-related alterations, reduces the levels of ischemia-associated pro-inflammatory factors, and maintains the expression of synaptic markers. PARP7-IN-27 can be used in studies related to ischemic stroke[1].
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PARP7-IN-27 | PARP7-IN-27 is a blood-brain barrier-permeable and selective PARP7 inhibitor with an IC50 of 22.8 nM. PARP7-IN-27 alleviates neuroinflammation and astrocyte activation, mitigates autophagy-related alterations, reduces the levels of ischemia-associated pro-inflammatory factors, and maintains the expression of synaptic markers. PARP7-IN-27 can be used in studies related to ischemic stroke. | |||||||||||||||||||||
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