3051817-48-9
3051817-48-9
Chemical Structure
EED-IN-3
- CAS No.: 3051817-48-9
- Formula:C25H29N3O5
- Molecular Weight:451.51
InChIKey: RXURRWSBNQVVIS-UHFFFAOYSA-N
SMILES: COC1=CC=C(C=C1)C2=NN(C(C(C(NCCCOC(C)C)=O)=C2)=O)C3=CC=C(C=C3)OC
Biological Activity: EED-IN-3 is an orally active EED inhibitor. EED-IN-3 effectively inhibits PRC2 by binding to EED (IC50 = 0.62 μM for EED) and downregulates H3K27me3. EED-IN-3 can efficiently and selectively inhibit PC3 cells with the IC50 of 3.69 μΜ and could significantly suppress colony formation and migration. EED-IN-3 can be used for research on prostate cancer[1].
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EED-IN-3 | EED-IN-3 is an orally active EED inhibitor. EED-IN-3 effectively inhibits PRC2 by binding to EED (IC50 = 0.62 μM for EED) and downregulates H3K27me3. EED-IN-3 can efficiently and selectively inhibit PC3 cells with the IC50 of 3.69 μΜ and could significantly suppress colony formation and migration. EED-IN-3 can be used for research on prostate cancer. | |||||||||||||||||||||
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Keywords
