3052303-53-1
3052303-53-1
Chemical Structure
RIPK3-IN-3
- CAS No.: 3052303-53-1
- Formula:C16H11N5S
- Molecular Weight:305.36
InChIKey: DCSISVAQAFTARM-UHFFFAOYSA-N
SMILES: C=CC1=NC=C2N=CN=C(NC3=CC(N=CS4)=C4C=C3)C2=C1
Biological Activity: RIPK3-IN-3 (compound 20) is a selective inhibitor of RIP kinase RIPK3 (IC50=10 nM). RIPK3 mediates the phosphorylation of Mixed Lineage Kinase (MLKL) and causes necroptosis, while RIPK3-IN-3 inhibits p-MLKL oligomerization and thereby inhibits necroptosis. RIPK3-IN-3 also downregulates CXCL5 secretion and inhibits AsPC-1 cell migration and invasion[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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RIPK3-IN-3 | 95.98% | RIPK3-IN-3 (compound 20) is a selective inhibitor of RIP kinase RIPK3 (IC50=10 nM). RIPK3 mediates the phosphorylation of Mixed Lineage Kinase (MLKL) and causes necroptosis, while RIPK3-IN-3 inhibits p-MLKL oligomerization and thereby inhibits necroptosis. RIPK3-IN-3 also downregulates CXCL5 secretion and inhibits AsPC-1 cell migration and invasion. | ||||||||||||||||||||
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