3054988-47-2
3054988-47-2
Chemical Structure
PARP1-IN-39
- CAS No.: 3054988-47-2
- Formula:C24H19F3N8O2
- Molecular Weight:508.46
InChIKey: PAHSTLHWASHYLV-UHFFFAOYSA-N
SMILES: CCNC(C1=CC=C(N2C=C3CN(CC3=N2)CC4=C(C5=C(N6N=CC(F)=C6C(N5)=O)C=C4)F)C(F)=N1)=O
Biological Activity: PARP1-IN-39 is an inhibitor of PARP1 with an IC50 of 0.22 nM. PARP1-IN-39 has an IC50 of 1.57 nM in human breast cancer cells. PARP1-IN-39 can be studied in breast, ovarian, pancreatic, and prostate cancers associated with DNA repair deficiencies, such as BRCA1/2 mutations[1].
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PARP1-IN-39 | PARP1-IN-39 is an inhibitor of PARP1 with an IC50 of 0.22 nM. PARP1-IN-39 has an IC50 of 1.57 nM in human breast cancer cells. PARP1-IN-39 can be studied in breast, ovarian, pancreatic, and prostate cancers associated with DNA repair deficiencies, such as BRCA1/2 mutations. | |||||||||||||||||||||
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