3055318-88-9
Chemical Structure
VVD-442
- CAS No.: 3055318-88-9
- Formula:C23H25BrClFN2O5S2
- Molecular Weight:607.94
IUPAC Name: (R,Z)-1-((5-bromo-2'-chloro-[1,1'-biphenyl]-2-yl)sulfonyl)-4-fluoro-N-(4-(methylsulfonyl)but-3-en-2-yl)piperidine-4-carboxamide
InChIKey: UVOHTEVCFZCFGW-IHWMJMDHSA-N
SMILES: BrC1=CC(C2=C(Cl)C=CC=C2)=C(S(N3CCC(C(N[C@H](C)/C=C\S(C)(=O)=O)=O)(F)CC3)(=O)=O)C=C1
Biological Activity: VVD-442 is an inhibitor targeting PI3Kα. VVD-442 covalently binds to Cys242 in the RAS-binding domain of PI3K p110α, induces conformational changes, and disrupts the interaction between PI3K p110α and RAS proteins. VVD-442 also blocks RAS-mediated PI3K activation. VVD-442 can be used in research related to RAS-mutant cancers and HER2-overexpressing cancers[1].
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VVD-442 | 99.97% | VVD-442 is an inhibitor targeting PI3Kα. VVD-442 covalently binds to Cys242 in the RAS-binding domain of PI3K p110α, induces conformational changes, and disrupts the interaction between PI3K p110α and RAS proteins. VVD-442 also blocks RAS-mediated PI3K activation. VVD-442 can be used in research related to RAS-mutant cancers and HER2-overexpressing cancers. | ||||||||||||||||||||
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