3064086-31-0
3064086-31-0
Chemical Structure
dASK1
- CAS No.: 3064086-31-0
- Formula:C38H38F2N10O8
- Molecular Weight:800.77
InChIKey: NYIDUKMXSLPHBJ-UHFFFAOYSA-N
SMILES: O=C(NCCOCCNC1=CC=CC(C(N2C3C(NC(CC3)=O)=O)=O)=C1C2=O)CCC(NC4=C(F)C=C(F)C(C(NC5=NC(C6=NN=CN6C(C)C)=CC=C5)=O)=C4)=O
Biological Activity: dASK1 is a PROTAC degrader of ASK1 that recruits cereblon. dASK1 promotes ASK1 degradation in a dose- and time-dependent manner via the ubiquitin-proteasome pathway. dASK1 can be used in studies of metabolic dysfunction-associated steatohepatitis[1].
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dASK1 | dASK1 is a PROTAC degrader of ASK1 that recruits cereblon. dASK1 promotes ASK1 degradation in a dose- and time-dependent manner via the ubiquitin-proteasome pathway. dASK1 can be used in studies of metabolic dysfunction-associated steatohepatitis. | |||||||||||||||||||||
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