3068529-37-0
3068529-37-0
Chemical Structure
PLK1-IN-15
- CAS. Nr.: 3068529-37-0
- Formula:C25H29N7O4S
- Molecular Weight:523.61
SMILES: O=C(OC)C1=C(SC2=C1CCCC2)NC3=NC(NC4=CC=C(N5CCN(C)CC5)C=C4)=NC=C3[N+]([O-])=O
Biological Activity: PLK1-IN-15 (Compound 7n) is a PLK1 inhibitor (IC50: 38.5 nM). PLK1-IN-15 exhibits antiproliferative activity against HepG2, Huh7, H1299 and A549 cells (IC50: 2.03, 2.08, 4.79 and 17.11 μM, respectively). PLK1-IN-15 induces cell cycle arrest at the G2/M phase and apoptosis, and has anticancer activity[1].
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PLK1-IN-15 | PLK1-IN-15 (Compound 7n) is a PLK1 inhibitor (IC50: 38.5 nM). PLK1-IN-15 exhibits antiproliferative activity against HepG2, Huh7, H1299 and A549 cells (IC50: 2.03, 2.08, 4.79 and 17.11 μM, respectively). PLK1-IN-15 induces cell cycle arrest at the G2/M phase and apoptosis, and has anticancer activity. | |||||||||||||||||||||
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References
Keywords
