3075862-29-9
Chemical Structure
MOR antagonist 2 hydrochloride
- CAS No.: 3075862-29-9
- Formula:C28H31ClN4O4
- Molecular Weight:523.02
InChIKey: BORXOGLQDHQJDW-SVZZUJDWSA-N
SMILES: O[C@]12[C@@H]3N(CC4CC4)CC[C@@]15C6=C(C=CC(O)=C6O[C@H]5[C@H](CC2)NC(C7=NC=CC8=C7NC=C8)=O)C3.Cl
Biological Activity: MOR antagonist 2 hydrochloride is a blood-brain barrier-permeable μ-opioid receptor (MOR) antagonist, with an IC50 of 28.37 nM, an EC50 of 4.25 nM, and a Ki of 0.18 nM against MOR. MOR antagonist 2 hydrochloride stabilizes the inactive conformation of MOR to reduce receptor activation levels. MOR antagonist 2 hydrochloride antagonizes analgesic effects in the mouse warm-water tail-flick test. MOR antagonist 2 hydrochloride induces fewer opioid withdrawal symptoms (wet dog shakes, paw tremors) in mice with opioid withdrawal symptoms. MOR antagonist 2 hydrochloride can be used for the research of opioid use disorder[1].
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MOR antagonist 2 hydrochloride | MOR antagonist 2 hydrochloride is a blood-brain barrier-permeable μ-opioid receptor (MOR) antagonist, with an IC50 of 28.37 nM, an EC50 of 4.25 nM, and a Ki of 0.18 nM against MOR. MOR antagonist 2 hydrochloride stabilizes the inactive conformation of MOR to reduce receptor activation levels. MOR antagonist 2 hydrochloride antagonizes analgesic effects in the mouse warm-water tail-flick test. MOR antagonist 2 hydrochloride induces fewer opioid withdrawal symptoms (wet dog shakes, paw tremors) in mice with opioid withdrawal symptoms. MOR antagonist 2 hydrochloride can be used for the research of opioid use disorder. | |||||||||||||||||||||
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