3077205-52-5
Chemical Structure
PSMA-MAL-5
- CAS No.: 3077205-52-5
- Formula:C65H94N12O20
- Molecular Weight:1363.51
IUPAC Name: (((S)-1-carboxy-5-((S)-2-((1S,4S)-4-(((S)-2-(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido)-6-(2-(4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecan-1-yl)acetamido)hexanamido)methyl)cyclohexane-1-carboxamido)-3-(naphthalen-1-yl)propanamido)pentyl)carbamoyl)-L-glutamic acid
InChIKey: ZKXKNKKBLVNTOR-BNDWKSPBSA-N
SMILES: O=C([C@@H]1CC[C@H](CC1)CNC([C@H](CCCCNC(CN2CCN(CCN(CCN(CC2)CC(O)=O)CC(O)=O)CC(O)=O)=O)NC(CCCCCN3C(C=CC3=O)=O)=O)=O)N[C@H](C(NCCCC[C@@H](C(O)=O)NC(N[C@H](C(O)=O)CCC(O)=O)=O)=O)CC4=CC=CC5=C4C=CC=C5
Biological Activity: PSMA-MAL-5 is a PSMA ligand. PSMA-MAL-5 covalently binds to Cys466 of PSMA. PSMA-MAL-5 labeled with 177Lu and 225Ac has high radiostability and tumor uptake. PSMA-MAL-5 also effectively inhibits tumor growth. PSMA-MAL-5 can be used for SPECT/CT imaging and radionuclide therapy of prostate cancer[1].
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PSMA-MAL-5 | PSMA-MAL-5 is a PSMA ligand. PSMA-MAL-5 covalently binds to Cys466 of PSMA. PSMA-MAL-5 labeled with 177Lu and 225Ac has high radiostability and tumor uptake. PSMA-MAL-5 also effectively inhibits tumor growth. PSMA-MAL-5 can be used for SPECT/CT imaging and radionuclide therapy of prostate cancer. | |||||||||||||||||||||
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