3077254-39-5
Chemical Structure
CYP1B1-IN-9
- CAS No.: 3077254-39-5
- Formula:C16H9Cl3N2OS
- Molecular Weight:383.68
InChIKey: UYAZEIAQRTVQME-UHFFFAOYSA-N
SMILES: O=C(C1=NC(C2=CC=CC(Cl)=C2)=CS1)NC3=CC(Cl)=CC(Cl)=C3
Biological Activity:
CYP1B1-IN-9 is a highly selective and competitive CYP1B1 Inhibitor with IC50 values of 1.48 nM, > 100 μM, and > 80 μM for CYP1B1, CYP1A1, and CYP1A2, respectively. CYP1B1-IN-9 significantly inhibits the migration and invasion of A549/T cells. CYP1B1-IN-9 has the ability to resensitize Paclitaxel (HY-B0015)-resistant cells, and good metabolic stability and safety, and shows favorable pharmacokinetic parameters. CYP1B1-IN-9 can be used for the study of tumor-drug resistance[1].
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CYP1B1-IN-9 | CYP1B1-IN-9 is a highly selective and competitive CYP1B1 Inhibitor with IC50 values of 1.48 nM, > 100 μM, and > 80 μM for CYP1B1, CYP1A1, and CYP1A2, respectively. CYP1B1-IN-9 significantly inhibits the migration and invasion of A549/T cells. CYP1B1-IN-9 has the ability to resensitize Paclitaxel (HY-B0015)-resistant cells, and good metabolic stability and safety, and shows favorable pharmacokinetic parameters. CYP1B1-IN-9 can be used for the study of tumor-drug resistance. |
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