3077446-86-4
Chemical Structure
LDs-BCA
- CAS No.: 3077446-86-4
- Formula:C34H29BF2N2O4
- Molecular Weight:578.41
InChIKey: IUJXXOQKQHUJOD-OQKWZONESA-N
SMILES: CCN(CC)C1=CC(O2)=C(C=C1)C3=O[B+3]([F-])([F-])O=C([C-]3C2=O)/C=C/C(C=C4)=CC=C4N(C5=CC=CC=C5)C6=CC=CC=C6
Biological Activity: LDs-BCA is a BF2-chelated AIE fluorescent probe with a positive solvatochromic effect, which can specifically target intracellular lipid droplets (Ex/Em = 565/620-730 nm). LDs-BCA monitors the dynamic changes in the morphology, size and quantity of intracellular lipid droplets under oleic acid induction and starvation stress. LDs-BCA, after intraperitoneal injection, accumulates in the gastric fat of living obese mice, allowing continuous monitoring via its fluorescent signal. LDs-BCA is applicable to studies related to intracellular lipid droplet polarity imaging and in vivo gastric fat visualization[1][2][3].
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LDs-BCA | LDs-BCA is a BF2-chelated AIE fluorescent probe with a positive solvatochromic effect, which can specifically target intracellular lipid droplets (Ex/Em = 565/620-730 nm). LDs-BCA monitors the dynamic changes in the morphology, size and quantity of intracellular lipid droplets under oleic acid induction and starvation stress. LDs-BCA, after intraperitoneal injection, accumulates in the gastric fat of living obese mice, allowing continuous monitoring via its fluorescent signal. LDs-BCA is applicable to studies related to intracellular lipid droplet polarity imaging and in vivo gastric fat visualization. | |||||||||||||||||||||
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References
- [1]. Lai C, et al. BF group chelated AIE fluorescent probe for polarity mapping of lipid droplets in cells and in vivo. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2022 Mar 05;268:120637. [Content Brief]
- [2]. Lee M M S, et al. Visualizing intracellular dynamics with AIE probes[J]. Materials Chemistry Frontiers, 2023, 7(15): 2973-2994.
- [3]. Li X, et al. Recent Advances in Near-Infrared Probes for Monitoring Drug Treatment Responses: Toward Efficacy Evaluation and High-Throughput Screening[J]. Chemical & Biomedical Imaging, 2026.
