3078678-28-8
3078678-28-8
Chemical Structure
EGFR-IN-179
- CAS No.: 3078678-28-8
- Formula:C23H18N4O4S
- Molecular Weight:446.48
InChIKey: PPAIOEQFKJNBPT-UHFFFAOYSA-N
SMILES: OS(C(C(C=CC=C1)=C1C=C2)=C2NC3=NC(NCC4=CC=CO4)=C(C=CC=C5)C5=N3)(=O)=O
Biological Activity: EGFR-IN-179 (Compound 8d) is an EGFR inhibitor (IC50: 0.068 μM for EGFR L858R/T790M/C797S; 2.56 μM for EGFR-WT-TK). EGFR-IN-179 has anticancer activity against non-small cell lung cancer[1].
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EGFR-IN-179 | EGFR-IN-179 (Compound 8d) is an EGFR inhibitor (IC50: 0.068 μM for EGFR L858R/T790M/C797S; 2.56 μM for EGFR-WT-TK). EGFR-IN-179 has anticancer activity against non-small cell lung cancer. | |||||||||||||||||||||
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