EGFR-IN-179
EGFR-IN-179 (Compound 8d) is an EGFR inhibitor (IC50: 0.068 μM for EGFR L858R/T790M/C797S; 2.56 μM for EGFR-WT-TK). EGFR-IN-179 has anticancer activity against non-small cell lung cancer.
For research use only. We do not sell to patients.
- CAS No.: 3078678-28-8
- Formula: C23H18N4O4S
- Molecular Weight:446.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
All EGFR Isoforms
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Biological Activity
Description
IC50 & Target
IC50: 0.068 μM for EGFR L858R/T790M/C797S; 2.56 μM for EGFR-WT-TK[1]
Chemical Information
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CAS No. 3078678-28-8
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Molecular Weight 446.48
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Formula C23H18N4O4S
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SMILES
OS(C(C(C=CC=C1)=C1C=C2)=C2NC3=NC(NCC4=CC=CO4)=C(C=CC=C5)C5=N3)(=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EGFR-IN-179 Related Classifications
HY-178442 Related Classifications
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