3082125-66-1
Chemical Structure
MET Transcription-IN-1
- CAS No.: 3082125-66-1
- Formula:C24H16N4O2
- Molecular Weight:392.41
InChIKey: VMTIVGKUCJQTTB-UHFFFAOYSA-N
SMILES: COC1=CC(C2=CC=C(O2)C(N3)=NC4=C3C(C=CC=N5)=C5C6=C4C=CC=N6)=CC=C1
Biological Activity: MET Transcription-IN-1 (Compound C3) is an orally active MET transcription inhibitor. MET Transcription-IN-1 can efficiently bind and stabilize the G-quadruplex in the MET promoter region, thereby inhibiting c-Met expression. MET Transcription-IN-1 can also overcome drug resistance caused by specific c-Met mutations. MET Transcription-IN-1 is capable of inhibiting tumor cell proliferation, migration, and invasion, as well as inducing cell cycle arrest and apoptosis. MET Transcription-IN-1 has antitumor activity, and can be used in the research of tumors such as non-small cell lung cancer[1].
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MET Transcription-IN-1 | MET Transcription-IN-1 (Compound C3) is an orally active MET transcription inhibitor. MET Transcription-IN-1 can efficiently bind and stabilize the G-quadruplex in the MET promoter region, thereby inhibiting c-Met expression. MET Transcription-IN-1 can also overcome drug resistance caused by specific c-Met mutations. MET Transcription-IN-1 is capable of inhibiting tumor cell proliferation, migration, and invasion, as well as inducing cell cycle arrest and apoptosis. MET Transcription-IN-1 has antitumor activity, and can be used in the research of tumors such as non-small cell lung cancer. | |||||||||||||||||||||
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