3084825-09-9
Chemical Structure
Nav1.2-IN-1
- CAS No.: 3084825-09-9
- Formula:C20H18F3N3
- Molecular Weight:357.37
InChIKey: HZELEYBPNCPQCZ-UHFFFAOYSA-N
SMILES: FC(C1=CC=C(C=C1)CN2CC=C(C3=CNC4=CC=CN=C43)CC2)(F)F
Biological Activity: Nav1.2-IN-1 (compound 5i), a 3-(1,2,3,6-tetrahydropyridine)-4-azaindole derivative, is a potent and selective Nav1.2 inhibitor. Nav1.2-IN-1 induces a reduction in the peak amplitude of Nav1.2 currents with an IC50 value of 7.79 μM. Nav1.2-IN-1 exhibits antiepileptic activity. Nav1.2-IN-1 shows high anticonvulsant effect and low neurotoxicity in subcutaneous Pentetrazole (sc-PTZ)-induced epilepsy mode[1].
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Nav1.2-IN-1 | Nav1.2-IN-1 (compound 5i), a 3-(1,2,3,6-tetrahydropyridine)-4-azaindole derivative, is a potent and selective Nav1.2 inhibitor. Nav1.2-IN-1 induces a reduction in the peak amplitude of Nav1.2 currents with an IC50 value of 7.79 μM. Nav1.2-IN-1 exhibits antiepileptic activity. Nav1.2-IN-1 shows high anticonvulsant effect and low neurotoxicity in subcutaneous Pentetrazole (sc-PTZ)-induced epilepsy mode. | |||||||||||||||||||||
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Keywords
