3086824-79-2
Chemical Structure
EXEL-1855
- CAS No.: 3086824-79-2
- Formula:C26H29F7N8O2
- Molecular Weight:618.55
InChIKey: PYFJFNDFGNQMQW-XMMPIXPASA-N
SMILES: O=C(N(CC[C@@](C(F)(F)F)(O)C1)C21CC2)NC3=CNN=C3C(N=C4)=CC5=C4C(N6CC(C6)C(F)(F)F)=NN5CC(C)(C)F
Biological Activity: EXEL-1855 is an orally active, potent and selective PLK4 inhibitor with an IC50 of 7.7 nM. EXEL-1855 competitively inhibits the catalytic activity of PLK4 by specifically binding to PLK4 (Met91 residue) to block centriole biogenesis, while relieving its ubiquitination-mediated degradation feedback, leading to abnormal protein accumulation and ultimately causing mitotic defects and death of tumor cells. EXEL-1855 can be used for research on neuroblastoma[1].
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EXEL-1855 | EXEL-1855 is an orally active, potent and selective PLK4 inhibitor with an IC50 of 7.7 nM. EXEL-1855 competitively inhibits the catalytic activity of PLK4 by specifically binding to PLK4 (Met91 residue) to block centriole biogenesis, while relieving its ubiquitination-mediated degradation feedback, leading to abnormal protein accumulation and ultimately causing mitotic defects and death of tumor cells. EXEL-1855 can be used for research on neuroblastoma. | |||||||||||||||||||||
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