3090685-19-8
3090685-19-8
Chemical Structure
HRZ-01-082-5
- CAS No.: 3090685-19-8
- Formula:C27H26N6O4S
- Molecular Weight:530.60
SMILES: O=C1NC(C(CC1)N2C(C3=CC=C(C4=C(NC56CC7CC(C6)CC(C5)C7)N8N=CSC8=N4)C=C3C2=O)=O)=O
Biological Activity: HRZ-01-082-5 is an analog of Glutarimide (HY-I0466). HRZ-01-082-5 is a dual-functional molecular glue degrader of SALL4 and OSR1 with a DC50 4.8 nM for OSR1. HRZ-01-082-5 significantly induced SALL4 and OSR1 degradation through CRBN. HRZ-01-082-5 can be used for heart and urogenital development, as well as cancers research[1].
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HRZ-01-082-5 | HRZ-01-082-5 is an analog of Glutarimide (HY-I0466). HRZ-01-082-5 is a dual-functional molecular glue degrader of SALL4 and OSR1 with a DC50 4.8 nM for OSR1. HRZ-01-082-5 significantly induced SALL4 and OSR1 degradation through CRBN. HRZ-01-082-5 can be used for heart and urogenital development, as well as cancers research. | |||||||||||||||||||||
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References
Keywords
