3095423-83-6
3095423-83-6
Chemical Structure
HPK1-IN-69
- CAS No.: 3095423-83-6
- Formula:C22H24N8O
- Molecular Weight:416.48
InChIKey: OHUYVOIWPDQJCB-UHFFFAOYSA-N
SMILES: CN1CCN(CC1)C2=CC=C(C=C2C#N)C3=CN=C(N)C(OCC4=CC=NC(N)=C4)=N3
Biological Activity: HPK1-IN-69 is an orally active HPK1 inhibitor with an IC50 of 1.7 nM. HPK1-IN-69 inhibits the HPK1-mediated TCR signaling pathway, reduces the phosphorylation level of SLP76, and promotes the release of IL-2. HPK1-IN-69 exhibits in vivo anti-tumor activity in mouse models. HPK1-IN-69 can be used for the research of colorectal cancer and MC38 syngeneic tumors[1].
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HPK1-IN-69 | HPK1-IN-69 is an orally active HPK1 inhibitor with an IC50 of 1.7 nM. HPK1-IN-69 inhibits the HPK1-mediated TCR signaling pathway, reduces the phosphorylation level of SLP76, and promotes the release of IL-2. HPK1-IN-69 exhibits in vivo anti-tumor activity in mouse models. HPK1-IN-69 can be used for the research of colorectal cancer and MC38 syngeneic tumors. | |||||||||||||||||||||
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References
Keywords
