3097630-45-7
Chemical Structure
YNW-1
- CAS No.: 3097630-45-7
- Formula:C39H45N9O4
- Molecular Weight:703.83
InChIKey: WZJMGVILOMPSEH-GDLZYMKVSA-N
SMILES: O=C1N([C@@H]2CCCN(C(C=C)=O)C2)C3=NC(NC4=CC=C(N5CCN(C)CC5)C=C4OC)=NC=C3C=C1N6C(C=CC=C7C)=C7N(C(C=C)=O)CC6
Biological Activity: YNW-1 is a dual-site irreversible EGFR covalent inhibitor. YNW-1 simultaneously covalently modifies the Cys775 and Cys797 residues of EGFR, thereby inhibiting multiple mutant forms of EGFR. YNW-1 inhibits p-EGFR, p-ERK, and p-AKT downstream signaling, and exhibits broad activity against Del19, T790M, C797S, exon 20 insertion, and rare EGFR mutants, with kinome selectivity. YNW-1 can be used for research related to non-small cell lung cancer[1].
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YNW-1 | YNW-1 is a dual-site irreversible EGFR covalent inhibitor. YNW-1 simultaneously covalently modifies the Cys775 and Cys797 residues of EGFR, thereby inhibiting multiple mutant forms of EGFR. YNW-1 inhibits p-EGFR, p-ERK, and p-AKT downstream signaling, and exhibits broad activity against Del19, T790M, C797S, exon 20 insertion, and rare EGFR mutants, with kinome selectivity. YNW-1 can be used for research related to non-small cell lung cancer. | |||||||||||||||||||||
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