3097973-97-9
3097973-97-9
Chemical Structure
(R)-ACBI-4
- CAS No.: 3097973-97-9
- Formula:C50H63N15O4S
- Molecular Weight:970.20
InChIKey: BLVMQMPRWNDEDM-FQCFDYAESA-N
SMILES: CC([C@H](N1N=NC2=C1CC[C@@H](CCCN3C[C@@H](N(CCC3)C4=NC(C5=NOC([C@@]6(C7=C(CCC6)SC(N)=C7C#N)C)=N5)=CC=N4)C)C2)C(N8C[C@@H](C[C@H]8C(NCC9=CC=C%10C(N(N=C%10)C)=C9)=O)O)=O)C
Biological Activity: (R)-ACBI-4 is an isomer of ACBI-4 (HY-176792). ACBI-4 is a selective GTP-loaded active state of KRAS (KRAS(on)) PROTAC degrader. ACBI-4 has significant anti-proliferative effect and potently degrades multiple KRAS mutants in cancer cells, such as KRASG12R[1].
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(R)-ACBI-4 | (R)-ACBI-4 is an isomer of ACBI-4 (HY-176792). ACBI-4 is a selective GTP-loaded active state of KRAS (KRAS(on)) PROTAC degrader. ACBI-4 has significant anti-proliferative effect and potently degrades multiple KRAS mutants in cancer cells, such as KRASG12R. | |||||||||||||||||||||
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Keywords
