3097995-73-5
Chemical Structure
Nav1.7-IN-19
- CAS No.: 3097995-73-5
- Formula:C23H23BrClFN4O5S
- Molecular Weight:601.87
InChIKey: ANJBRPRCZWHHKE-UHFFFAOYSA-N
SMILES: NC(C(C1CC1)NCCCC2=C(C=CC(Cl)=C2)OC3=C(C=C(C(F)=C3)S(=O)(NC4=NOC=C4)=O)Br)=O
Biological Activity: Nav1.7-IN-19 is a potent, selective and orally active Nav1.7 inhibitor with an IC50 of 0.49 μM. Nav1.7-IN-19 shows high selectivity for Nav1.7, with selectivities of 312-fold and 662-fold against Nav1.1 and Nav1.5 in the inactivated state. Nav1.7-IN-19 exhibits weak inhibition on hERG potassium channels. Nav1.7-IN-19 exhibits analgesic effect and can be used for the research of neurological disease[1].
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Nav1.7-IN-19 | 98.87% | Nav1.7-IN-19 is a potent, selective and orally active Nav1.7 inhibitor with an IC50 of 0.49 μM. Nav1.7-IN-19 shows high selectivity for Nav1.7, with selectivities of 312-fold and 662-fold against Nav1.1 and Nav1.5 in the inactivated state. Nav1.7-IN-19 exhibits weak inhibition on hERG potassium channels. Nav1.7-IN-19 exhibits analgesic effect and can be used for the research of neurological disease. | ||||||||||||||||||||
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Keywords
