3105974-36-2
Chemical Structure
PAD2/4-IN-1
- CAS No.: 3105974-36-2
- Formula:C26H27Cl2N7O
- Molecular Weight:524.44
IUPAC Name: (S)-2-amino-2-(1-(5-(3,5-dichloro-6-(1-methyl-1H-pyrazol-3-yl)pyridin-2-yl)isoquinolin-1-yl)piperidin-4-yl)-N-methylacetamide
InChIKey: XOZZIKVERFKUOI-QFIPXVFZSA-N
SMILES: O=C(NC)[C@@H](N)C1CCN(C2=NC=CC3=C2C=CC=C3C4=NC(C5=NN(C)C=C5)=C(Cl)C=C4Cl)CC1
Biological Activity: PAD2/4-IN-1 (Compound 4f) is an orally active inhibitor of PAD2 and PAD4 with IC50 values of 23 nM and 10 nM, respectively. PAD2/4-IN-1 can inhibit protein citrullination in neutrophils and reduce hERG channel liabilities. PAD2/4-IN-1 can be used in the research of autoimmune diseases, neurological disorders, and cancers[1].
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PAD2/4-IN-1 | PAD2/4-IN-1 (Compound 4f) is an orally active inhibitor of PAD2 and PAD4 with IC50 values of 23 nM and 10 nM, respectively. PAD2/4-IN-1 can inhibit protein citrullination in neutrophils and reduce hERG channel liabilities. PAD2/4-IN-1 can be used in the research of autoimmune diseases, neurological disorders, and cancers. | |||||||||||||||||||||
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