3109603-86-0
Chemical Structure
DPP8/9-IN-2
- CAS No.: 3109603-86-0
- Formula:C30H30F3N3O2
- Molecular Weight:521.57
IUPAC Name: (S)-2-amino-4-(4-(bis(4-fluorophenyl)methyl)piperidin-1-yl)-1-(5-fluoroisoindolin-2-yl)butane-1,4-dione
InChIKey: AXNJBRPWGQXSJY-MHZLTWQESA-N
SMILES: O=C(N1CC2=C(C=C(F)C=C2)C1)[C@@H](N)CC(N3CCC(C(C4=CC=C(F)C=C4)C5=CC=C(F)C=C5)CC3)=O
Biological Activity: DPP8/9-IN-2 (Compound 21) is a DPP8/9 inhibitor with IC50 values of 0.22 nM and 3 nM, respectively, and Ki values of 2.9 nM and 6 nM, respectively . DPP8/9-IN-2 has certain cardiotoxicity, with IC50 values of 0.7 μM, 29.0 μM and 27.7 μM for hERG potassium channel, Nav1.5 sodium channel and Cav1.2 calcium channel, respectively. DPP8/9-IN-2 can be used in the research of diseases such as tumors[1].
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DPP8/9-IN-2 | DPP8/9-IN-2 (Compound 21) is a DPP8/9 inhibitor with IC50 values of 0.22 nM and 3 nM, respectively, and Ki values of 2.9 nM and 6 nM, respectively . DPP8/9-IN-2 has certain cardiotoxicity, with IC50 values of 0.7 μM, 29.0 μM and 27.7 μM for hERG potassium channel, Nav1.5 sodium channel and Cav1.2 calcium channel, respectively. DPP8/9-IN-2 can be used in the research of diseases such as tumors. | |||||||||||||||||||||
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