3110002-64-4
Chemical Structure
FGFR2-IN-4
- CAS No.: 3110002-64-4
- Formula:C25H20N8O
- Molecular Weight:448.48
InChIKey: DICKGCNITDYTHW-UHFFFAOYSA-N
SMILES: C=CC(NC1=CC=C(C2=C(C#CC3=CN=C(N(C)C=N4)C4=C3)C5=C(N)N=CN=C5N2C)C=C1)=O
Biological Activity: FGFR2-IN-4 is a selective, orally active FGFR2 inhibitor, with IC50 values of 10.0 nM and 5.8 nM against wild-type FGFR2 and the FGFR2V565F mutant, respectively. FGFR2-IN-4 induces necroptosis in FGFR2-driven tumor cells. FGFR2-IN-4 induces tumor regression in xenograft models harboring FGFR2 inhibitor-resistant mutations without altering serum phosphate levels. FGFR2-IN-4 is used to investigate FGFR2-driven malignancies, including intrahepatic cholangiocarcinoma and gastric cancer[1].
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FGFR2-IN-4 | FGFR2-IN-4 is a selective, orally active FGFR2 inhibitor, with IC50 values of 10.0 nM and 5.8 nM against wild-type FGFR2 and the FGFR2V565F mutant, respectively. FGFR2-IN-4 induces necroptosis in FGFR2-driven tumor cells. FGFR2-IN-4 induces tumor regression in xenograft models harboring FGFR2 inhibitor-resistant mutations without altering serum phosphate levels. FGFR2-IN-4 is used to investigate FGFR2-driven malignancies, including intrahepatic cholangiocarcinoma and gastric cancer. | |||||||||||||||||||||
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