3113161-60-4
3113161-60-4
Chemical Structure
NLRP3-IN-96
- CAS No.: 3113161-60-4
- Formula:C23H26ClFN4O2
- Molecular Weight:444.93
InChIKey: XACQVUFSLBPHPQ-UHFFFAOYSA-N
SMILES: CCCOC1=C(CN2N=NC(C(N(C(C)C)CC3=CC=C(F)C=C3)=O)=C2)C=C(Cl)C=C1
Biological Activity: NLRP3-IN-96 is a blood-brain barrier-penetrant NLRP3 inhibitor with a human Kd value of 556 nM. NLRP3-IN-96 inhibits NLRP3 inflammasome activation, suppresses IL-1β release and reduces NLRP3 expression, and inhibits TNF-α production through an NLRP3-independent pathway. NLRP3-IN-96 can be used for research on neuropathic pain[1].
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NLRP3-IN-96 | NLRP3-IN-96 is a blood-brain barrier-penetrant NLRP3 inhibitor with a human Kd value of 556 nM. NLRP3-IN-96 inhibits NLRP3 inflammasome activation, suppresses IL-1β release and reduces NLRP3 expression, and inhibits TNF-α production through an NLRP3-independent pathway. NLRP3-IN-96 can be used for research on neuropathic pain. | |||||||||||||||||||||
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