3114056-16-2
Chemical Structure
DOTAGA-FAP-2286-ALB
- CAS No.: 3114056-16-2
- Formula:C91H131IN16O25S3
- Molecular Weight:2072.21
InChIKey: RUFQJQXIMQPEBF-CONACXLJSA-N
SMILES: O=C(CC[C@@H](C(N[C@H](C(O)=O)CCCCNC(CCCC1=CC=C(I)C=C1)=O)=O)NC(CCC(C(O)=O)N2CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC2)=O)NCCSCC3=CC(CSC[C@@H](C(N4[C@H](C(N5[C@H](C(N[C@@H]([C@H](O)C)C(N[C@H](C(N[C@H]6CC7=CC=CC=C7)=O)CCC(N)=O)=O)=O)CCC5)=O)CCC4)=O)NC(CCCCC)=O)=CC(CSC[C@@H](C(O)=O)NC6=O)=C3
Biological Activity: DOTAGA-FAP-2286-ALB is a derivative of Rofapitide tetraxetan (HY-147057). DOTAGA-FAP-2286-ALB is a selective fibroblast activation protein (FAP) inhibitor with an IC50 value of 67.5 nM. DOTAGA-FAP-2286-ALB enhances tumor retention via albumin interaction, prolonging blood circulation and improving radiometal complex stability (e.g., with 111In and 225Ac). DOTAGA-FAP-2286-ALB is promising for research of radionuclide therapy (TRT) of FAP-positive solid tumors[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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DOTAGA-FAP-2286-ALB | 99.29% | DOTAGA-FAP-2286-ALB is a derivative of Rofapitide tetraxetan (HY-147057). DOTAGA-FAP-2286-ALB is a selective fibroblast activation protein (FAP) inhibitor with an IC50 value of 67.5 nM. DOTAGA-FAP-2286-ALB enhances tumor retention via albumin interaction, prolonging blood circulation and improving radiometal complex stability (e.g., with 111In and 225Ac). DOTAGA-FAP-2286-ALB is promising for research of radionuclide therapy (TRT) of FAP-positive solid tumors. | ||||||||||||||||||||
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