3116532-77-2
Chemical Structure
BZZ-034
- CAS No.: 3116532-77-2
- Formula:C21H25NO6
- Molecular Weight:387.43
InChIKey: KISDNHLRILSGBJ-UHFFFAOYSA-N
SMILES: COC(C=CC(C1=CC2=C(C=C1C(NCC(C)C)=O)OCO2)=C3OC)=C3OC
Biological Activity: BZZ-034 is an orally active and selective PXR dual agonist with an IC50 of 0.47 μM against human PXR. BZZ-034 binds to the PXR ligand-binding domain, activates PXR-mediated transcription, and upregulates the expression of downstream CYP3A4/Cyp3a11 and Oatp2 target genes. BZZ-034 induces physiological hepatomegaly, centrilobular hepatocellular hypertrophy, and periportal hepatocellular proliferation, and accelerates liver regeneration after partial hepatectomy. BZZ-034 can be used for research on liver regeneration[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
BZZ-034 | BZZ-034 is an orally active and selective PXR dual agonist with an IC50 of 0.47 μM against human PXR. BZZ-034 binds to the PXR ligand-binding domain, activates PXR-mediated transcription, and upregulates the expression of downstream CYP3A4/Cyp3a11 and Oatp2 target genes. BZZ-034 induces physiological hepatomegaly, centrilobular hepatocellular hypertrophy, and periportal hepatocellular proliferation, and accelerates liver regeneration after partial hepatectomy. BZZ-034 can be used for research on liver regeneration. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
