3124168-27-7
Chemical Structure
nNOS-IN-2 trihydrochloride
- CAS No.: 3124168-27-7
- Formula:C27H31Cl3N4O
- Molecular Weight:533.92
InChIKey: WNHBFPFLESFMPM-UHFFFAOYSA-N
SMILES: N=C(C1=CC=CO1)NC2=CC=CC(CNCCC3=CC=C(C4=CC=CC=C4)C=C3CN)=C2.Cl.Cl.Cl
Biological Activity: nNOS-IN-2 trihydrochloride is a blood-brain barrier-permeable nitric oxide synthase (nNOS) inhibitor. nNOS-IN-2 trihydrochloride exhibits Ki values of 1.7 nM and 2.3 nM against human and rat nNOS, respectively, and shows high selectivity for human eNOS and iNOS. nNOS-IN-2 trihydrochloride also effectively reduces PD-L1 expression in human melanoma cells under both basal conditions and IFN-γ exposure. nNOS-IN-2 trihydrochloride can be used for the study of melanoma and related signaling pathways[1].
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nNOS-IN-2 trihydrochloride | nNOS-IN-2 trihydrochloride is a blood-brain barrier-permeable nitric oxide synthase (nNOS) inhibitor. nNOS-IN-2 trihydrochloride exhibits Ki values of 1.7 nM and 2.3 nM against human and rat nNOS, respectively, and shows high selectivity for human eNOS and iNOS. nNOS-IN-2 trihydrochloride also effectively reduces PD-L1 expression in human melanoma cells under both basal conditions and IFN-γ exposure. nNOS-IN-2 trihydrochloride can be used for the study of melanoma and related signaling pathways. | |||||||||||||||||||||
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