3126212-40-3
3126212-40-3
Chemical Structure
PT-129
- CAS No.: 3126212-40-3
- Formula:C46H48N8O12S
- Molecular Weight:936.98
InChIKey: OBXQUMZRCNMVCZ-FOCZVASCSA-N
SMILES: O=C(NC1=CC=C(NC(CCOCCOCCOCCNC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O)=O)C=C1)[C@@H](NS(=O)(CC(N5N=CC6=C5C=CC=C6)=O)=O)CC7=CC=CC=C7
Biological Activity: PT-129 is a G3BP1/G3BP2 PROTAC degrader. PT-129 inhibits the formation of stress granules, disassembles pre-existing stress granules, disrupts stress granule-mediated ATF4 trafficking via migratory exocytosis, and suppresses cancer cell proliferation. PT-129 is applicable to the research of lung cancer and melanoma[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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PT-129 | 98.66% | PT-129 is a G3BP1/G3BP2 PROTAC degrader. PT-129 inhibits the formation of stress granules, disassembles pre-existing stress granules, disrupts stress granule-mediated ATF4 trafficking via migratory exocytosis, and suppresses cancer cell proliferation. PT-129 is applicable to the research of lung cancer and melanoma. | ||||||||||||||||||||
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