3194-36-3
Chemical Structure
SU-4029 dihydrochloride
- CAS No.: 3194-36-3
- Formula:C9H21Cl2N3O
- Molecular Weight:258.19
IUPAC Name: 3-(azepan-1-yl)-N-hydroxypropanimidamide dihydrochloride
InChIKey: KBDUAOSAXOGJIE-UHFFFAOYSA-N
SMILES: N=C(CCN1CCCCCC1)NO.Cl.Cl
Biological Activity: Su-4029 is an agent that interacts with alpha receptors. It negates the blockade of norepinephrine by the reversible adrenergic blocker phentolamine but not by the irreversible blocker Dibenamine, suggesting Su-4029 acts at the same site as these blockers. Su-4029 pretreatment results in three categories of responses to pressor phenylalkylamines: irreversible blockade of amines with no or only p-hydroxylation, reversible blockade of amines with beta-carbon hydroxylation, and no blockade or augmentation of amines with m and p-hydroxylation or m or p plus beta-hydroxylation. Su-4029 may deform the alpha receptor site affected by adrenergic blocking agents[1].
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SU-4029 dihydrochloride | Su-4029 is an agent that interacts with alpha receptors. It negates the blockade of norepinephrine by the reversible adrenergic blocker phentolamine but not by the irreversible blocker Dibenamine, suggesting Su-4029 acts at the same site as these blockers. Su-4029 pretreatment results in three categories of responses to pressor phenylalkylamines: irreversible blockade of amines with no or only p-hydroxylation, reversible blockade of amines with beta-carbon hydroxylation, and no blockade or augmentation of amines with m and p-hydroxylation or m or p plus beta-hydroxylation. Su-4029 may deform the alpha receptor site affected by adrenergic blocking agents. | |||||||||||||||||||||
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Keywords
