326823-27-2
Chemical Structure
PNU-292137
- CAS No.: 326823-27-2
- Formula:C18H17N3O
- Molecular Weight:291.35
IUPAC Name: N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(naphthalen-2-yl)acetamide
InChIKey: RIGZCVNCFXYBEG-UHFFFAOYSA-N
SMILES: O=C(CC1=CC=C2C=CC=CC2=C1)NC3=NNC(C4CC4)=C3
Biological Activity: PNU-292137 is an orally active, potent CDK2 inhibitor with IC50s of 37 nM and 92 nM for CDK2/cyclin A and CDK2/cyclin E, respectively. PNU-292137 makes interactions with the hydrophobic pocket at the back of the CDK2 ATP pocket. PNU-292137 efficiently inhibits tumor cell proliferation in human colon and prostate tumor cell lines. PNU-292137 exhibits antitumor activity (TGI>50%) in a mouse xenograft model[1].
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PNU-292137 | 99.95% | PNU-292137 is an orally active, potent CDK2 inhibitor with IC50s of 37 nM and 92 nM for CDK2/cyclin A and CDK2/cyclin E, respectively. PNU-292137 makes interactions with the hydrophobic pocket at the back of the CDK2 ATP pocket. PNU-292137 efficiently inhibits tumor cell proliferation in human colon and prostate tumor cell lines. PNU-292137 exhibits antitumor activity (TGI>50%) in a mouse xenograft model. | ||||||||||||||||||||
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